PURPOSE:This study aimed to evaluate the safety, tolerability and pharmacokinetics of the combination of oral vinorelbine with erlotinib using the conventional (CSV) and metronomic (MSV) dosing schedules in patients with advanced non-small cell lung cancer (NSCLC).METHODS:This was an open-label, multiple dose-escalation phase I study.An alternating
In order to improve working accuracy of motor unit of mine cable winding car, aiming at problems of load disturbance and speed adjustment in the Ointment operation control of cable motor and reel motor, a cross-coupling control method for motor of mine cable winding car was proposed.Fruit fly optimization algorithm (FOA) is used to optimize PI para
IntroductionWe have acquired significant knowledge regarding the pathogenesis of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2).However, the underlying mechanisms responsible for disease recovery still need to be fully understood.MethodsTo gain insights into critical immune markers involved in COVID-19 etiopathogenesis, we s